Brigatinib User Guide

Brigatinib User Guide

Brigatinib User Guide
What is brigatinib?
Non-small cell lung cancer cells that have moved to different parts of the human body are
treated using Brigatinib. Brigatinib is especially used when all other treatments for cancer have
failed.
If the patient has cancer which has a particular genetic marker (not normal “ALK” gene),
Brigatinib is used only in that condition. Doctor has to test the patient for this particular gene.
Other than that, Brigatinib may also be taken for conditions not mentioned in the medication
guide.
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How should I take brigatinib?
Patient is required to adhere to all instructions of their doctor and go through all medication
guides or instruction sheets. Doctor’s are been known to alter the dosage strength as per the
patient’s requirements. Patients should strictly adhere to the doctor’s instructions.
Normally, Brigatinib is to be taken only once every 24 hours, with or without food.
Patient should make sure that the tablet is taken in full and not crushed or chewed.
If the patient vomits out the Brigatinib tablet after consuming one, they should not take
another tablet. Next tablet should be taken on the next day, thereby sticking to the usual
dosage schedule.
Consumption of Brigatinib is not advised to be stopped without proper consultation with your
doctor.
Brigatinib should be kept at room temperature and away from moisture and high temperature.
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What should I avoid while taking brigatinib?
Brigatinib is not compatible with Grapefruit. Interaction with grapefruit can lead to many side-
effects. Therefore consuming grapefruit while under treatment is not advisable.

Blurred vision and impairment of reactions can be caused by treatment of Brigatinib. While the
treatment is going on, patients should try to avoid driving or any dangerous activities unless
reactions to Brigatinib are clear.
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Brigatinib side effects
Immediate medical attention should be sought if any of the following reactions begin to
surface: hives, breathlessness, swelling on the face, lips or throat.
Immediate doctor’s assistance should be taken if the patient goes through any of these:
• lung problems--cough, trouble breathing, chest pain, fever;
• vision problems--blurred vision, double vision, increased sensitivity to light, seeing
flashes of light or "floaters" in your vision;
• high blood pressure--severe headache, pounding in your neck or ears, dizziness;
• high blood sugar--increased thirst, increased urination, hunger, nausea, fruity breath
odor, weakness, confusion;
• heart problems--very slow heartbeats, feeling like you might pass out;
• muscle problems--unexplained muscle pain or weakness; or

• Pancreatitis--upper stomach pain (worse with eating and may spread to your back),
nausea, weight loss.

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Is it safe to take Brigatinib with other drugs?
At times, there are some medicines that are not recommended to be taken with other
medicines. One medicine can affect the blood level of other medicines, which can affect the
efficacy of the other medicine, or the patient may experience certain side effects.
A lot of medicines can react with Brigatinib, including OTC medicines, prescription drugs,
supplements, and herbal medicines. It is impossible to notify all such interactions. Before
starting treatment with Brigatinib, patients are advised to tell their doctors about any ongoing
medicines.
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